Varki et al. revealed that the polymorphic paired receptors Siglec-5 and Siglec-14 modulate neutrophil and amnion responses to group B streptococcus, with Siglec-14 counteracting immune suppression by GBS, and highlight the impact of a Siglec-14-null polymorphism on susceptibility to infection and potential risk for prematurity [17]. This evidence concerns the gene SIGLEC14 and infection.