CD274 and neoplasm: It has been shown that in preclinical lung cancer mouse models, [225Ac]Ac-DOTA-4AH29 and [131I]I-GMIB-4AH29 exhibited high and sustained tumor targeting, which prolonged the survival of mice with aggressive tumors; furthermore, the binding of PD-L1 ICB to [225Ac]Ac-DOTA-4AH29 TRT enhanced its efficacy [200].