Li et al. demonstrated that CAF markers, including α-SMA, vimentin, and CAF-specific factors such as CXC motif chemokine ligand 2 (CXCL12), FGF10, interleukin-6 (IL-6), and collagen type I alpha 1 chain (COL1A1), were highly expressed in senescent fibroblasts, which contributed to the promotion of lung cancer cell migration and invasion. This evidence concerns the gene CXCL12 and lung cancer.