Cardiac biomarkers such as troponins (cTnI and cTnT), creatine kinase MB (CK-MB), brain natriuretic peptide (BNP), and high-sensitivity C-reactive protein (hs-CRP) play a pivotal role in diagnosing acute coronary syndromes (ACS), heart failure, and other cardiovascular conditions [13]. Here, TNNI3 is linked to heart failure.