Kafaie et al. applied three algorithms, namely, BOolean Operation-based Screening and Testing (BOOST), FastEpistasis, and Tree-based Epistasis Association Mapping (TEAM), to genome-wide association studies (GWAS) data of colorectal cancer (CRC) to identify interacting genetic risk factors, and key genes such as MACF1, USP49, SMAD2, SMAD3, TGFBR1, RHOA, and CCDC32 were highlighted. The gene discussed is MACF1; the disease is colorectal carcinoma.