Further analyses showed that E-cadherin and Smad7 were increased while N-cadherin and TGF-β1 were decreased in the tumor tissues of the mice [40], suggesting that MACF1 may control metastasis through regulating the epithelial–mesenchymal transition, and thus, MACF1 could be a therapeutic target for the treatment of melanoma. The gene discussed is MACF1; the disease is neoplasm.