MACF1 depletion decreased AML cell proliferation, decreased Runx2 expression, and repressed the activation of PI3K/Akt signaling, suggesting that MACF1 participates in AML cell proliferation through activating the PI3K/Akt signaling pathway and increasing Runx2 expression [33]. The gene discussed is PIK3CA; the disease is acute myeloid leukemia.