The protein level of hairy/enhancer of split 1 (HES1), the transcription factor that was implicated in the inhibition of bone formation [77] and osteogenic differentiation [78], was upregulated in the femur tissues of the older group of patients with osteoporosis aged 80–95 (vs. the group aged 60–79) and in 21-month-old mice (vs. the group aged 6 months). The gene discussed is HES1; the disease is osteoporosis.