Several transcription factors linked with β-cell neogenesis, and cellular metabolic and immune stress were upregulated in PDAC-associated diabetes, including Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ), Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) and Forkhead Box P1 (FOXP1), as well as a pro-apoptotic gene, BCL2 Like 11 (BCL2L11) (Supplementary Table S1). Here, BCL2L11 is linked to diabetes mellitus.