Moreover, in neuropathic pain, Drp1 has been linked to imbalances in ROS homeostasis, the formation of mPTP through Bax/and Bak, as well as regulation by calcium signaling pathways, all of which support our hypothesis that mitochondrial dysfunction contributes to the development and progression of DPN [119] and thus could serve as a therapeutic target. This evidence concerns the gene BAK1 and neuropathic pain.