However, we found that ElaI-VMP1 mice maintained conserved kidney histoarchitecture, with only isolated areas of tubular necrosis and debris in the lumen, in contrast to WT mice, which exhibited large areas of acute tubular necrosis, desquamation, pyknosis, and loss of nuclei—typical damage seen in acute renal failure associated with SAP (Figure 4). Here, VMP1 is linked to acute kidney injury.