Although the malaria-responsive expression of the genes Fga, Fgb, and Fgg, encoding the subunits of the APP fibrinogen, was not vaccination-responsive, the transcript levels of genes involved in the coagulation cascade, such as F2, encoding the zymogen prothrombin, F7, F8, F9, F10, and F13b, were highly significantly increased in the liver of vaccinated mice during the crisis, whereas, concomitantly, the expression of these genes continued to decrease in unvaccinated mice. This evidence concerns the gene APP and malaria.