The gene Plat, encoding the plasminogen activator, which is tissue-type, showed a very low constitutive expression in both unvaccinated and vaccinated mice, and responded almost identically to malaria, with a relatively slow increase in expression, until peak parasitaemia was reached at day 8 p.i. During the crisis phase, however, Plat expression continued to increase in unvaccinated mice, reaching a maximum towards the end of the crisis at day 11 p.i., whereas it decreased significantly at the same time in vaccinated mice (Figure 3B). Here, PLAT is linked to malaria.