Our data show that transcript levels of Serping1 respond directly to vaccination: (i) vaccination per se increased the constitutive transcript levels of Serping1; (ii) upon infection with P. chabaudi malaria, Serping1 mRNA increased more rapidly, with an early peak on day 1 p.i., in vaccinated mice, whereas the peak in unvaccinated mice was delayed on day 4 p.i.; (iii) the decline in Serping1 mRNA levels after the peak on day 1 p.i. towards day 8 p.i. was accelerated in vaccinated mice, before increasing again towards the end of the crisis, due to overall recovery from infection. The gene discussed is SERPING1; the disease is malaria.