To this end, the following topics will be addressed: (1) pro-survival and anti-apoptosis signals, (2) integrin expression induced by drug stimulation, (3) drug transporters, (4) ECM, (5) epithelial-to-mesenchymal transition (EMT), (6) cancer stem cell (CSC) property, (7) tyrosine kinase inhibitors (TKIs), (8) PD-L1, and (9) glycosylation. This evidence concerns the gene CD274 and cancer.