In addition, α7β1 integrin regulates the stemness of HCC cell lines SMMC-7221 and Hep G2 and esophageal SCC cell lines KYSE180 and KYSE520 by activating the PTK2-PI3K/Akt and FAK signaling pathways [96,97]. This evidence concerns the gene PTK2 and hepatocellular carcinoma.