Moreover, αvβ3 integrin plays a pivotal role in mediating resistance to HER2 and EGFR-TKI neratinib-induced ferroptosis through the reprogramming of the iron/antioxidant metabolism and sustained activation of Akt signaling in murine HER2-positive brain metastatic breast cancer cell line TBCP-1 [105]. Here, ERBB2 is linked to breast carcinoma.