Cancer cells can acquire drug resistance through integrin-mediated pro-survival and anti-apoptosis signals, including PI3K/Akt/mTOR, Ras/Raf/MAPK/ERK, NF-κB, JAK/STAT, YAP, and Wnt/β-catenin [40,41,42] (Figure 3). The gene discussed is YAP1; the disease is cancer.