Miat, EZH2-associated lncRNA, and Rncr4 may contribute to the reduction in the severity of renal cystic disease in Tsc1KO mice; however, the functions of these lncRNAs need to be further examined to define their role in the regulation of cystogenesis in Tsc1KO mice and TSC renal cystic disease in general. The gene discussed is EZH2; the disease is cystic kidney disease.