ERBB2 and cancer: The phosphorylated products interact with multiple intracellular signaling pathways (such as the phosphoinositide-3-kinase/protein-kinase-B, PI3K/AKT, and anti-apoptosis pathway, for which HER2 is the most potent stimulator), regulating genes involved in cancer cell proliferation, survival, differentiation, angiogenesis, invasion, and metastasis [62,66,67,68,69,70,71].