Further, disrupted DNA replication and repair processes lead to genomic instability and impaired cell proliferation [129], which we have demonstrated to be features of CTA, given MetS with the differential expression of the establishment of sister chromatid cohesion, cohesin loading onto chromatin, and SLBP-dependent processing of replication-dependent histone pre-mRNAs. This evidence concerns the gene SLBP and metabolic syndrome.