SMC3 and cancer: To further evaluate the pan-cancer role of FAM111B in the DNA replication process, we constructed a protein–protein interaction (PPI) network graph, which identified interactions between FAM111B and 40 other genes, including genes that encode (SMC3, SMC1A) and regulate (ESCO2) the cohesion complex (Figure 2A) [18], an integral component of the replication fork [19].