These pathways included signal transduction (mTOR signaling pathway, phosphatidylinositol signaling system, MAPK signaling pathway, AMPK signaling pathway), endocrine and metabolic diseases (type 2 diabetes, insulin resistance, non-alcoholic fatty liver disease), neurodegenerative diseases (spinocerebellar ataxia, Alzheimer’s disease), carbohydrate metabolism (inositol phosphate metabolism), lipid metabolism (biosynthesis of unsaturated fatty acids), and cancer-related pathways (Table S3). This evidence concerns the gene MTOR and early-onset autosomal dominant Alzheimer disease.