Research on microgravity has also revealed significant effects on cancer biology, including the formation of multicellular spheroids (MCS), the reorganization of the cytoskeleton, and the regulation of key proteins such as p53 (a tumor suppressor), NF-κB (a regulator of immune responses and inflammation), and BAX (a pro-apoptotic protein involved in programmed cell death). The gene discussed is NFKB1; the disease is neoplasm.