This is further supported by the increased predicted instability of SCYL2 in our patient, which is −2.34 kcal/mol, compared to the two previously reported missense mutations that are only associated with a mild phenotype consisting of developmental delay, which have stability changes of −0.63 and −0.11 kcal/mol, respectively (Figure 3C). This evidence concerns the gene SCYL2 and Global developmental delay.