FOXO1 and alveolar rhabdomyosarcoma: In addition, the characteristic PAX3-FOXO1 gene fusion of alveolar rhabdomyosarcoma (aRMS) appears to be associated with miR-486-5p, which induces changes in the exosomal contents originating from myoblasts and acts as a pro-oncogenic signal to promote migration, infiltration, and colony formation [19].