Furthermore, M1 macrophages activate the STAT3/NF-κB signalling pathway in breast cancer cells through inflammatory cytokines (IL-6, TNF-α, and IL-1β), which then triggers the activation of the lin-28b–let-7–hmga2 axis, causing an EMT and inducing the formation of CSCs [137]. The gene discussed is IL6; the disease is breast carcinoma.