A high level of myoepithelial integrin-β6 is a biomarker indicative of high-risk DCIS in a heterocellular spheroid model of DCIS, which promotes the MMP13-related myoepithelial-led invasion of luminal cells through the TGF-β-dependent stimulation of EP300, which epigenetically modulates myoepithelial-derived MMP13 expression [151]. The gene discussed is EP300; the disease is ductal breast carcinoma in situ.