In CKD, IL-6 is released by renal cells (such as tubular epithelial cells, podocytes, and mesangial cells), endothelial cells, adipose tissue, and lymphocytes under the influence of stimuli such as lipopolysaccharide (LPS), TNF-α, IL-1β, and oxidative stress [47,48]. This evidence concerns the gene IL6 and chronic kidney disease.