The carcinogenesis of CRC is a multistep process involving the accumulation of genetic mutations and epigenetic modifications, involving lncRNAs like GAS5 and CASC8 as important modulators in key signaling pathways like the Wnt/β-catenin and Hippo/YAP, which play a major role in tumor initiation and progression [42,43,44]. This evidence concerns the gene GAS5 and colorectal carcinoma.