In this respect, the aim of our study was to examine the relationship between the GAS5 rs145204276 and CASC8 rs10505477 polymorphisms and the susceptibility to CRC through a case-control study in a Romanian population (an Eastern European population), an ethnic group in which the association between these polymorphisms and CRC susceptibility has not previously been studied. This evidence concerns the gene CASC8 and colorectal carcinoma.