In this respect, the aim of our study was to examine the relationship between the GAS5 rs145204276 and CASC8 rs10505477 polymorphisms and the susceptibility to CRC through a case-control study in a Romanian population (an Eastern European population), an ethnic group in which the association between these polymorphisms and CRC susceptibility has not previously been studied. The gene discussed is GAS5; the disease is colorectal carcinoma.