Crosstalk has been described between the androgen receptor and NGF in human prostate cancer cells, observing that the inhibition of androgen signaling impaired NGF-induced cell proliferation, and vice versa; the blockade of the NGF receptor, tropomyosin receptor kinase A (TrkA), decreases the mitogenic effect of androgen [54]. Here, NTRK1 is linked to Familial prostate cancer.