In animal models, it was observed that Schwann cells participate in the epithelial–mesenchymal transition (EMT) by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3 beta (GSK-3β)/Snail-Twist signaling pathway, hence supporting the invasiveness and metastasis of lung cancer [40]. This evidence concerns the gene AKT1 and lung cancer.