ADRB2 and neoplasm: In other work, the chemical denervation of sympathetic nerves in a mouse model of small-cell lung cancer (SCLC) reduced tumor growth; furthermore, the sympathetic effect on tumor growth was mediated by the adrenergic receptor ADRB2 since its inhibition reduced the growth of SCLC xenografts and human organoids by disrupting PKA signaling [36].