Expectedly, using this model found that the DAF-2 insulin/IGF-1 signaling pathway has therapeutic potential for ALS; for instance, downregulation of DAF-2 signaling or silencing of cytokinin homologs grp1 or efa-6 was observed to significantly reduce SOD1 aggregation and improve movement defects in hmSOD1 mutant G85R nematodes [121]. This evidence concerns the gene INS and amyotrophic lateral sclerosis.