The upregulation of B7H3 expression has been observed in various malignant neoplasms, including non-small cell lung cancer (NSCLC), renal, urothelial, prostate, gastric, pancreatic, colorectal, and ovarian cancers, as well as osteosarcoma, head and neck squamous carcinoma, and glioblastoma. This evidence concerns the gene CD276 and cancer.