In a case-control study involving 265 patients with essential hypertension, a combined APEX1 rs1760944-rs3136817-rs1130409 single nucleotide polymorphism (SNP) showed differential distribution between hypertensive patients and normotensive controls, with a specific G-T-T haplotype having a statistically higher prevalence in hypertensive patients. This evidence concerns the gene APEX1 and essential hypertension.