Our present findings suggest that apixaban could ameliorate renal injury in streptozotocin-induced type 1 diabetic rats, partly by blocking the crosstalk between the AGE-RAGE-oxidative stress axis and the thrombin-PAR-1/factor Xa-PAR-2 system in diabetic kidneys. The gene discussed is F2RL1; the disease is type 1 diabetes mellitus.