Fenobam, an mGlu5 antagonist, has an analgesic in rodents, and reduces sensitization in humans [152,153]. Undesired side effects such as cognitive impairment and sedation [152] limit its useNAM mGlu5 antagonist ADX10059, attenuates vasodilator responses to meningeal stimulation in a rodent model in the same way as naratriptan, and reduces TCC neuronal firing in response to dural stimulation [154]. Here, GRM5 is linked to Cognitive impairment.