To conclude, SCU may ameliorate liver fibrosis by altering the abundance of Bifidobacterium, Lactobacillus, and Allobaculum; regulating linoleic acid, the glycerophospholipid metabolism, and the production of unsaturated fatty acids; and downregulating PI3K/AKT signaling pathway. Here, AKT1 is linked to Hepatic fibrosis.