Interestingly, in salivary gland adenoid cystic carcinoma, under hypoxic conditions, HIF-1α binds to the promotor of NID1 to upregulate NID1 expression and increases cancer cell invasion and migration via the PI3K/AKT-EMT pathway [25]. The gene discussed is HIF1A; the disease is salivary gland adenoid cystic carcinoma.