Other pathways involved in breast cancer development include Sonic Hedgehog (SHH) signaling, transforming growth factor-β/small mothers against decapentaplegic (TGF-β/SMAD), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) [221]. This evidence concerns the gene NFKB1 and breast cancer.