IGHE and Alzheimer disease: In mice exhibiting DfE-induced AD-like pathology, we observed significant increases in histamine, IgE (Figure 3A,B), and the inflammatory chemokines RANTES, MDC, TARC, MCP-1, MIG, MIL-1α, MIL-1β, and BLC (Figure 3C–J), along with the inflammatory cytokines TNF-α, IL-6, IL-4, and IL-5 (Figure 3K–N), compared to the normal group.