According to some studies, the alternative alleles of rs12778366 and rs7895833 polymorphisms in the promoter region of the SIRT1 gene are associated with AMD, T2DM, obesity, glucose tolerance, hypertension development risk, and preeclampsia [38,39,40,41,42,43,44]. The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.