SIRT1 and obesity due to melanocortin 4 receptor deficiency: The polymorphic variants rs12778366 and rs7895833 in the SIRT1 gene promoter region, according to few studies, are associated with age-related macular degeneration (AMD), type 2 diabetes mellitus (T2DM), obesity, glucose tolerance, the risk of hypertension, and PE [38,39,40,41,42,43,44].