Even though glabridin has been reported to cause cancer cell cycle arrest and proliferation inhibition by downregulating the Braf/MEK [32] and JNK1/2 signaling pathways [33], in this study, glabridin prevented the MC3T3-E1 preosteoblast cell cycle arrest and proliferation inhibition induced by oxidative stress. This evidence concerns the gene MAP2K7 and cancer.