HAO1 and breast cancer: A significant number of these genes have been linked to breast cancer, MANSC domain containing 1 (MANSC1) [39], PLK1 [40], family with sequence similarity 98 member A (FAM98A) [31], CHP2 [41], msh homeobox 1 (MSX1) [42], cytokine like 1 (CYTL1) [43], fibrinogen C domain containing 1 (FIBCD1) [44], hydroxyacid oxidase 1 (HAO1) [45], AlkB homolog 7 (ALKBH7) [46], DYRK2 [47], fatty acid binding protein 7 (FABP7) [48], etc. Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT).