TARDBP and amyotrophic lateral sclerosis: TDP-43 inclusions are the morphological hallmark of amyotrophic lateral sclerosis (ALS) and a subset of frontotemporal lobe degeneration (FTLD-TDP), but TDP-43 inclusion has been identified in age-related neurodegenerative disorders, referred to as limbic-predominant age-related TDP-43 encephalopathy (LATE) [38].