While microinfarcts, atherosclerosis, arteriolosclerosis, cerebral amyloid angiopathy (CAA) and tau pathology have an impact on disease progression and cognitive impairment (CI) [8,9], others, like β-amyloid (Aβ) and transactive response DNA binding protein of 43 kDa (TDP-43), do not seem to contribute to PD progression [10,11]. This evidence concerns the gene MAPT and Parkinson disease.