(i) arthritis severity ↓(ii) pain behavior ↓(iii) weight loss ↓(iv) osteoporosis and bone erosion score ↓(v) inflammatory cell infiltration ↓(vi) synovial thickening ↓(vii) no effect on joint space narrowing and cartilage destruction(viii) NF-κB and p50 homodimer DNA-binding activity ↓(ix) p50-positive cells in the cartilage and in the synovium ↓(x) sensory neuropeptide (SP, CGRP) production ↓. The gene discussed is NFKB1; the disease is osteoporosis.