When co-cultured with RA-CD4+ T cells, ONX-0914 increased RA-FLS apoptosis and decreased their invasive ability, viability, and inflammation (as suggested by decreased IL-6, CCL2, MMP1, and MMP3 levels), although it had a lesser impact on the RA-FLSs when they were without CD4+ T cells in the co-culture [139]. The gene discussed is MMP1; the disease is rheumatoid arthritis.