(i) Th1, Th17↓; Th2, Treg↑(ii) FLS apoptosis ↑(iii) FLS invasiveness and viability ↓(iv) inflammatory markers (IL-6, CCL2, MMP1, MMP3) ↓(v) arthritis score ↓(vi) synovial hyperproliferation ↓(vii) articular injury ↓(viii) serum TNFα, IL-1β, and IFNγ ↓(ix) synovial cell apoptosis ↑(x) BCL2, Vimentin, and VEGF expression in the synovium ↓. The gene discussed is TNF; the disease is arthritic joint disease.