(i) arthritis score and thickness of paws ↓(ii) inflammatory cell infiltration ↓(iii) erosion score ↓(iv) TNFα, IL-1β, IL-6, MMP-3, iNOS, and COX-2 levels ↓(v) joint destruction on micro-CT ↓(vi) no adverse effects. This evidence concerns the gene TNF and arthritic joint disease.