Circ_RUSC2 (also named hsa_circ_0002702), which originates from exon 2 of the RUN and SH3 domain-containing 2 (RUSC2) gene, has been reported to facilitate the vascular smooth muscle cell (VSMC) migration and proliferation by sponging miR-661 recently [13]; however, the role of circ_RUSC2 in CRC biology has not yet been clearly explained. Here, RUSC2 is linked to colorectal carcinoma.