Regarding neuromuscular diseases, not only mutations in HSPB8, but also mutations in BAG3 can cause myopathy with myofibrillar pathology (like that observed in HSPB8 myopathy) or axonal neuropathy, further supporting the crucial role of the CASA complex in maintaining the functional integrity of the neuromuscular system, including sarcomer [44]. Here, HSPB8 is linked to neuromuscular disease.