Following the detection of the first HSPB8 mutations in distal hereditary motor neuropathy (dHMN), discovered simultaneously with HSPB1 mutations as cause on another dHMN [4,5], mutations in HSPB8 have also been linked to Charcot–Marie–Tooth (CMT) disease and muscle disease. This evidence concerns the gene HSPB1 and distal hereditary motor neuropathy.