Further knockdown of PRAJA1 in 5xFAD mice resulted in a significant decrease in the frequency of mIPSCs in CA1 neurons (Figure 8Cb; HE-sc shRNA: 5.14 ± 0.48 Hz; HE-Pja1 shRNA: 3.19 ± 0.45 Hz; n = 9 cells per group, * p < 0.05), suggesting that reduced PRAJA1 may contribute to the elevated mIPSC frequency typically observed in this AD model. Here, PJA1 is linked to Alzheimer disease.