The discovery that PRAJA1 mediates the effects of the astrocytic membrane estrogen receptor G protein-coupled receptor 30 (GPR30) on learning and memory by binding to Serpina3 [14] provides a compelling link between astrocytic signaling, PRAJA1 expression, and cognitive function, even suggesting a potential therapeutic avenue for cognitive decline in peri- and postmenopausal women due to GPR30 positively regulating PRAJA1 expression through the CREB signaling pathway [14]. This evidence concerns the gene GPER1 and Mental deterioration.