Finally, while AD mice show an age-related increase in VGCC density, further knockdown of Pja1 in 5xFAD mice suppressed VGCC currents (Figure 8F; * p < 0.05 for WT vs. HE, #p < 0.05 for HE sc shRNA vs. HE Pja1 shRNA). The gene discussed is PJA1; the disease is Alzheimer disease.