LRP6 and Familial prostate cancer: Tahir et al. demonstrated that Cav-1 interacts with low-density lipoprotein receptor-related protein 6 (LRP6), forming a signaling platform that activates insulin-like growth factor receptor (IGF-IR) and IR, subsequently stimulating the Akt/mTORC1 pathway and promoting aerobic glycolysis in prostate cancer cells [134].