IRF3 and Alzheimer disease: Research demonstrates that 2′3′-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), a high-affinity and selective STING agonist, significantly improves cognitive function in AD mice, reduces Aβ plaque burden, decreases neuronal apoptosis, and ameliorates AD-related pathological changes by activating the cGAMP-STING-IRF3 signaling pathway [40].