Insulin-like Growth Factor-Binding Protein 7 (IGFBP-7) and Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) are biomarkers that have received considerable focus for their synergistic role in identifying early renal tubular stress and injury, especially in patients with CIN. Here, IGFBP7 is linked to cervical squamous intraepithelial neoplasia.