The CXCL8 chemokine, also known as interleukin 8 (IL8), is notably altered in the sera or cerebral fluid of patients affected by seizures originating from autoimmune-associated epilepsy [2], epileptic encephalopathy with spike-wave activation in sleep [3], drug-resistant epilepsy [4], mesial temporal lobe epilepsy (MTLE) [5], and even COVID-19 infection [6], underlying a master role of IL8 in epileptogenesis. Here, CXCL8 is linked to Epileptic encephalopathy.