In cases of CRB1-retinopathies where retinal lamination and scaffolding is affected due to abnormal function of both photoreceptors and Muller cells [2], the presence of CMO or lamellar pseudoholes may contraindicate subretinal injection due to the risk of complications like macular hole formation. The gene discussed is CRB1; the disease is chronic recurrent multifocal osteomyelitis.