An in vitro study performed on periodontal cells collected from patients with or without DM showed that a deficiency of the NAD+-dependent histone deacetylase, sirtuin-6 (SIRT6), led to the reduced resolution of inflammation, to the accumulation of apoptotic neutrophils, and to the modification of the efferocytosis process of macrophages by changing the levels of miR-216/217 and increasing the expression of CD36 and DEL-1, which could contribute to the progression or severity of periodontal disease in people with DM [27]. This evidence concerns the gene SIRT6 and diabetes mellitus.