No BS for either KLF14 or SREBF1 was identified in the promoters of MC4R, 5-HT2C, MC3R, S1PR2, FFAR1/GPR40, and HCR2 within this database, despite their known association with metabolic syndrome [28,29,30,31,32,33,34,35]. The gene discussed is S1PR2; the disease is metabolic syndrome.