On the other hand, not only do our results demonstrate that adhesion GPCRs with multiple binding sites for KLF14 and SREBF-1 (ADGRB2, ADGRD2, ADGRG1, CELSR1, ADGRE2, among others) are significantly associated with metabolic syndrome, but they are also consistent with previous studies linking these receptors to adipogenic function and glucose homeostasis [51]. The gene discussed is CELSR1; the disease is metabolic syndrome.