While our findings align with previous studies demonstrating the pivotal roles of KLF14 and SREBF-1 [56], with a strong association with High Density Lipoprotein cholesterol (HDL-C) levels, metabolic syndrome, and coronary heart disease [57,58], this research offers a novel perspective by identifying orphan GPCRs as potential targets for these transcription factors. This evidence concerns the gene KLF14 and coronary artery disorder.