Previous studies have also shown that HDCA acts as an inhibitor to alleviate NAFLD by promoting the expression of hepatic CYP7B1, as well as the abundance of probiotic species, such as those in the genus Parabacteroides in mice, thereby enhancing lipid catabolism via PPARα signaling (59). This evidence concerns the gene CYP7B1 and metabolic dysfunction-associated steatotic liver disease.