FGF21 and steatosis: Additionally, increased free fatty acids released from adipose tissue are transported to hepatocytes, wherein they are converted to triglycerides, which stimulate the production of FGF21, and in turn reduce serum triglycerides by stimulating energy metabolism and inhibiting mouse mammalian target of rapamycin complex 1 signaling, thereby contributing to a reduction in hepatic damage and steatosis (61).