In a mouse model of cholesterol gallstones, the activation of FXR-MRP3/MRP4 signaling has been demonstrated to be associated with a significant reduction in lithogenic diet-induced gallstones and hepatic steatosis following the administration of Limosilactobacillus reuteri and Lactiplantibacillus plantarum (54). The gene discussed is NR1H4; the disease is fatty liver disease.