In murine fibrosis models, knockdown or knockout of SPARC markedly attenuates hepatic fibrosis, partly by suppressing the trans-differentiation of hepatic stellate cells (HSCs) into a myofibroblasts-like phenotype and inhibiting myofibroblasts activation (Atorrasagasti et al., 2013; Camino et al., 2008). Here, SPARC is linked to Hepatic fibrosis.