Nowadays, growing evidence has emphasized the potential role of non-criteria antibodies in the diagnosis of SN-APS, including anti-phosphatidylserine-prothrombin (aPS/PT) antibodies, antibodies against the domain I of β2-glycoprotein (aDI), IgA aCL and aβ2GPI, antibodies to vimentin/CL complex, anti-annexin V antibodies/annexin A5 resistance (6). The gene discussed is F2; the disease is autoimmune polyendocrinopathy.