CD8A and Granuloma: Moreover, the cellular composition of granulomas evolves with the infection stage; early high-burden granulomas (four weeks post-infection) show a type 2 wound healing effect, driven by IL-13 and IL-4, while late low-bacterial-burden granulomas (ten weeks post-infection) are dominated by a type 1 response, characterized by a greater presence of cytotoxic CD8+ T cells by pro-inflammatory signaling networks (69).