Notably, CMV-related pathways are related to non-genomic actions of 1-25-dihydroxyvitamin D3 and IL-19 signaling, while EBV-related genes are involved in neurodegenerative and neurotrophic pathways, such as as prion disease pathway, leptin pathway, brain derived neurotrophic factor (BDNF) signaling, and pathways for maintenance of survival and functions of B cell, T cells and platelets, such as the IL-5 signaling pathway, thymic stromal lymphopoietin TSLP signaling, and PDGF signaling. The gene discussed is BDNF; the disease is prion disease.